Salata and Ghannoum and colleagues randomly assigned 221 patients at eight international centers to receive topical GV (5 mL of 0.00165% solution, swish and gargle and expectorate twice daily) or nystatin oral suspension (5mL of 100,000 units/mL swish and swallow four times daily) for 14 days.Īmong patients eligible for analysis, 68.5% of the 92 in the GV group had cure or improvement of OC, compared to 67.8% of the 90 patients on nystatin, a non-significant difference. To compare the two treatments head-to-head, Drs. Mahmoud Ghannoum, a co-author of the study and a Case Western colleague, tested more dilute concentrations in the lab and found they were strongly active against Candida. Salata noted, but its use has been limited because it causes bluish-purple staining that could be stigmatizing. GV, a dye that’s also used as an antiseptic, has been around for centuries, Dr. While antiretroviral treatment has made OC less common among HIV-positive individuals in wealthier countries, it remains common in resource-limited areas, with prevalence as high as one-third of people with HIV, he and his colleagues write in their report. OC is often the first presentation of HIV/AIDS, and can be very problematic and persistent in patients with more advanced disease, Dr. The findings were published online September 24 in the journal AIDS. Robert Salata of Case Western Reserve University in Cleveland, who worked on the new study, told Reuters Health in a telephone interview. “It was as effective, it was well tolerated, and it was much less expensive,” Dr. NEW YORK (Reuters Health) – Gentian violet (GV) is as effective as nystatin for treating oral candidiasis (OC) in AIDS patients, at a fraction of the cost per treatment, according to new findings.
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